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For use in cattle, beef cattle, swine, chickens, & turkeys

Category: Anti-Microbial

Species: Cattle, Pigs, Turkeys, Chickens

Active Ingredients: sodium sulfamethazine

prescription required

What is SMZ-Med® 454?

SMZ-Med® 454 is a soluble powder available in a 453.5 g foil pack that contains 100% sodium sulfamethazine.

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.


For the control and treatment of the following diseases when caused by one or more of the following pathogenic organisms susceptible to sulfamethazine.

cow product


For the treatment of:

  • Bacterial Pneumonia and Bovine Respiratory Disease Complex (Shipping Fever Complex) (Pasteurella spp.)
  • Colibacillosis (Bacterial Scours) (Escherichia coli)
  • Necrotic Pododermatitis (Foot Rot) (Fusobacterium necrophorum)
  • Calf Diphtheria (Fusobacterium necrophorum)
  • Acute Metritis (Streptococcus spp.)

Beef Cattle

For the treatment of:

  • Acute Mastitis (Streptococcus spp.)
pig product


For the treatment of:

  • Porcine Colibacillosis (Bacterial Scours) (Escherichia coli)
  • Bacterial Pneumonia (Pasteurella spp.)
chicken product


For the control of:

  • Infectious Coryza (Avibacterium paragallinarum)
  • Coccidiosis (Eimeria tenella, Eimeria necatrix)
  • Acute Fowl Cholera (Pasteurella multocida)
  • Pullorum Disease (Salmonella Pullorum)
turkey product


For the control of:

  • Coccidiosis (Eimeria meleagrimitis, Eimeria adenoeides)


  • Highly Soluble: Mixes readily and thoroughly in water
  • Convenient: Once-a-day dosage in drinking water or as a drench
  • Fast Acting: Symptom relief usually apparent in two to three days
  • Easy to Use: One packet/gallon of water prepares recommended 12.0% stock solution
  • Safe: Approved by FDA

Withdrawal Period

Meat and Offal10 days15 days10 days10 days
EggsDo not medicate chickens producing eggs for human consumption.Do not medicate turkeys producing eggs for human consumption.
MilkDo not use in female dairy cattle 20 months of age or older.

Additional Safety Information

  • Have only medicated water available during treatment. Ensure adequate drug dosage and water intake.
  • Cattle and calves not drinking or eating must be dosed by drench or with immediate sulfamethazine bolus.
  • For best results, treat animals individually.
  • Excessive dosage may cause toxic reactions.
  • Hatchability of eggs laid during medication with sulfas, and for short periods thereafter, may be adversely affected.

Pack Size

List No.Pack SizeCase Size
1SUL006453.5 g pouch20